Nanosecond pulsed electric fields in medical applications

Nanosecond pulsed electric fields (nsPEFs) have been primarily investigated for the potential of reversible electroporation in cancer therapy. It also open the doors for new medical treatments, for precise drugs deliveries, for genetics, for research, etc.

nsPEFs have been studied as a potential modality for tumour ablation and targeted cancer treatment. Similar to microsecond pulsed electric fields (msPEFs), nsPEFs can induce irreversible electroporation in tumour cells, leading to cell death. However, nsPEFs may offer advantages in terms of improved selectivity, reduced thermal effects, and potentially enhanced immune response compared to msPEFs.

nsPEFs have shown potential in promoting wound healing processes. Studies have suggested that nsPEFs can enhance cell migration, stimulate angiogenesis (formation of new blood vessels), and modulate the expression of growth factors and cytokines involved in wound healing.

To be reversible, the electroporation process is based on an exposure of the living cells to a very intense electric field (in the range of tens of kV/m) but for a very short duration (in the range of tens to a few hundreds of nanoseconds).

Montena designs new pulse generators based on solid state switching, especially designed for nanosecond pulsed electric field (nsPEF) applications.

Thanks to a modular architecture the pulsers of montena can deliver a large range of pulse intensity and duration.

new technology to accelerate wound healing
high hopes for improved cancer treatments
a new tool for gene therapy

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